Assistant Professor Li Tao has received an INBRE IV Junior Investigators (JIs) Award for his project, “Structural and Functional Analysis of Centralspindlin”. The INBRE IV JIs Award will provide substantial funding for up to 3 years at $100,000/year in direct costs. The Tao’s lab will center its research on the molecular mechanism through which centralspindlin regulates cytokinesis. Abnormal cell division (mitosis) causes cancer. Understanding the mechanism of cell division and its regulation has thus become a key to finding cures for cancer. Cytokinesis is the last gate to control cell division. Cytokinesis is dominated by a motor complex, centralspindlin. However, little is known of the structure and function of centralspindlin. This project will address a significant knowledge gap on the regulation of cytokinesis. It will also provide clues for the development of new anti-cancer therapies.
In photo: The Tao Lab (2018). L-R: Li Tao, Joshua Lawcock, Chelsea Blaquera, Marilyn Yamamoto, Kathleen Shon, and Jamae Balagot.