Students must receive approval from the Institutional Review Board (IRB) for theses or dissertations involving human subjects or from the Institutional Animal Care and Use Committee (IACUC) for theses or dissertations involving use of vertebrate animals. Approval from these institutional committees, where appropriate, must be sought at the time of approval of the thesis/dissertation topic, and research on the thesis or dissertation may not commence until after IRB approval is granted. Where appropriate, permission from other entities, such as the Office of Research Services and the UH Hilo Environmental Health & Safety Office, may be required.